颈动脉窦粥样硬化与冠状动脉粥样硬化程度相关

Association between atherosclerotic changes of carotid bifurcation and the extent of coronary atherosclerosis

目的:探讨颈动脉粥样硬化与冠心病程度的关系。方法:对285例可疑冠心病患者行冠脉造影检查,以B型超声仪检查颈动脉内中膜厚度(IM T)。用冠脉病变支数表示冠心病程度。采静脉血检查血脂水平。结果:颈动脉与冠状动脉粥样硬化有共同的危险因子,如增龄、肥胖、血脂异常。比较各组IM T差别发现,颈动脉窦的F值最大(左,右分别为65.64%,63.24%)。颈动脉窦粥样硬化对诊断冠心病的阳性预告值最大(左、右颈动脉窦分别为89.9%,88.8%)。结论:颈动脉窦IM T与冠心病程度明显相关。颈动脉窦IM T可以作为筛选冠心病的指标。

Objective：To investigate the correlation of carotid atherosclerosis with the presence and severity of coronary artery disease （CAD）. Methods ： Subjects who underwent coronary angiography for suspected CAD were evaluated by B-mode ultrasound with carotid intima-media thickness （IMT）. CAD extent was determined by the number of diseased vessels. Venous blood was sampled for the measurement of serum lipid concentration. Results： Carotid and coronary atherosclerosis shared many risk factors, such as aging, obesity and dyslipidemia. Carotid bifurcation took the maximal F value in the comparison of IMT values among groups （the F of left, right sino-carotid was 65.64%, 63.24% respectively）. Bifurcation also had the maximal positive predictive value for detecting CAD （the positive predictive valne of left. right sino-carotid was 89.9 %, 88.8 % respectively）. Conchsion： IMT in the carotid bifurcation is related significantly with the presence and extent of CAD. Carotid bifurcation IMT may be used as a surrogate marker for coronary atherosclerosis.