慢性肾脏病与冠心病相关性的临床研究

Study of the correction between chronic kidney disease and coronary artery disease

目的:探讨包括轻度肾损害在内的慢性肾脏病(CKD)与冠心病(CAD)的相关性。方法:收集我院2000年1月至2004年12月心内科和心胸外科符合入选标准的冠脉造影患者733例进行回顾性分析。按有、无冠心病分组,探讨慢性肾脏损害与冠心病的相关性。统计学处理采用Log istic多因素回归分析。结果:慢性肾脏病、高血糖、高血压、男性均为冠心病的重要危险因素。其中慢性肾脏病的危险最大(优势比OR=3.977)。结论:包括轻度肾损害在内的慢性肾脏病与冠心病显著相关,是冠心病的重要危险因素。

Objective： To investigate the correlation between coronary artery disease （CAD） and chronic kidney disease including minor renal dysfunction. Methods： A retrospective study was performed in 733 patients suspected of coronary artery disease underwent a selective coronary angiography and received a survey of risk factors during the hospitalization. According to the existence of CAD or not, these patients were divided into two groups. The correlation between CAD and chronic renal disease （CRD） was examined. Logistic regression was used in the statistic analysis. Results： Logistic regression analysis showed that chronic kidney disease, diabetes mellitus, hypertension, hypercholesterolemia and male sex were risk factors for CAD. CRD was the most important risk factor for CAD （OR = 3. 977）. Conclusion： Chronic renal disease including minor renal dysfunction is correlated significantly to coronary artery disease.