天山雪莲培养物含药血清对大鼠腹腔巨噬细胞一氧化氮释放的影响

Effect of Tissue Culture of Saussurea involucrata on Release of NO in Activated Peritoneal Macrophage

目的探讨天山)莲培养物的含药血清对大鼠腹腔巨噬细胞一氧化氮(NO)释放的影响。方法采用血清药理学方法,灌胃给予天山)莲培养物3g/kg体重。结果天山)莲培养物和原药材的醇提物0.5h含药血清对腹腔巨噬细胞NO释放的影响类似,能够抑制活化的腹腔巨噬细胞NO释放,且天山)莲培养物醇提物(TCSauI)的作用优于原药材醇提物(WSauI),而2h和4h的含药血清药效则有所差别。结论天山)莲培养物含药血清对大鼠腹腔巨噬细胞NO释放有一定影响。

Objective To study the effect of the tissue culture of Saussuma involucrata on the release of NO in activated peritoneal macrophage. Methods The tissue euhure of S. involucrata was administrated intragastrieally （i. g. ） at the dose of 3 g/kg b. w.. To investigate the effect of the tissue culture of S. involucrata on the release of NO in activated peritoneal macrophage of by using a method of serum pharmacology. Results The tissue euhure of S. involucrata and S. involucrata containing serum taken 0.5 h after ingestion could evidently inhibit the release of NO in activated peritoneal maerophage. Conclusion The tissue cuhure of S. involucrata had the effect of the release of NO in activated peritoneal macrophage.