难治性癫癎患者中神经节苷脂GM1抗体和谷氨酸脱羧酶抗体的研究

Antibodies to GM1 Ganglioside and Autoantibodies to Glutamic Acid Decarboxylase in Patients with Intractable Epilepsy

目的:研究难治性癫癎与血清神经节苷脂GM1抗体(GM1-A)及谷氨酸脱羧酶抗体(GAD-A)水平的关系,探讨其免疫学机制。方法:应用酶联免疫吸附法(ELISA)测定60例难治性癫癎(IE组)和60例非难治性癫癎(NE组)患者及60例健康对照组(HC组)血清GM1-A和GAD-A水平。结果:GM1-A和GAD-A水平,IE组与HC组和NE组比较显著增加(P<0.05),NE组与HC组比较差异无显著性意义。结论:GM1-A和GAD-A水平与难治性癫癎关系密切,提示难治性癫癎与自身免疫有关。

Objective：To study the relationship between the levels of antibodies to GM1 ganglioside （GM1-A） and autoantibodies to glutamic acid decarboxylase （GAD-A） and intractable epilepsy, in order to explore the pathogenic immunologic mechanisms of intractable epilepsy. Methods：Enzyme-linked immunosorbent assay （ELISA） was used to investigate the prevalence of GM1-A and GAD-A in patients with intractable epilepsy （n=60）, controlled epilepsy （n=60） and health controls （n=60）. Results： There was significant difference in the levels of GM1-A and GAD-A among intractable epilepsy, controlled epilepsy and health controls （P〈0.05）. Conclusion.. There was significant relationship between GM1-A, GAD-A and intractable epilepsy. Intractable epilepsy was associated with immunologic mechanism.