乙肝患者病变程度与病毒基因分型的相关性分析

Study on the relationship between the HBV genotype and its clinical status

目的探讨乙型肝炎(乙肝)病毒(HBV)基因分型与病变程度之间的关系。方法对165例经肝组织切片证实的急性轻型肝炎、轻度慢性肝炎(CHB)、中度慢性肝炎和重度慢性肝炎及肝硬化的乙肝患者血清进行基因分型。结果基因型以B型和C型为主,分别为12.1%和86.7%。C型中度慢性肝炎所占的百分比显著高于B型,而重度慢性肝炎在B型和C型中所占百分比差异无统计学意义;基因C型感染者HBeAg阳性率显著高于基因B型感染者,而基因C型感染者中HBeAb阳性率显著低于基因B型感染者。结论C型HBV感染和乙肝病情加重有一定关系,而B型HBV感染者预后相对较好。

Objective To study the relationship between the HBV genotype and its clinical status. Methods HBV gene sequencing analysis were conducted in 185 chronic asymptomatic. The damage of the histology was diagnosed by pathology. Results Most genotypes were B and C types（12.1% and 86.7% respectively）. The different damage of the liver in genotype distributing were significantly different, and there was a statistical significance in two types. Compared with genotype B, genotype C was more commonly found in severe damage, but heavy damage of patients has no statistical significance in B and C types. HBeAg positive rate in patients of genotype C was higher than that of genotype B, but HBeAb positive rate in patients of genotype C was lower than that of genotype B. Conclusion Genotype C is associated with the development of severe hepatitis B, and genotype B has a relatively good prognosis.