α-共核蛋白的结构和功能研究进展

Advancement of structure/function study in alpha-synuclein

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摘要 α-共核蛋白(αlpha-synuc le in)是一种突触前终末蛋白。它的免疫学反应存在于一些神经退行性结构如阿耳茨海默氏病(AD)包涵体的淀粉样蛋白斑和帕金森病(PD)的莱维小体之中。在非神经系统疾病中也发现了α-共核蛋白表达上调。α-共核蛋白在信号传递,神经可塑性和调节细胞分化及成活方面起一定作用。 Alpha-synuclein is presynaptic nerve terminal protein and its immunoreactivity has been observed in such neurodegenerative structures as senile plaques of Alzheimer＇ s disease or Lewy bodies of Parkinson＇ s disease. Alpha-synuclein has also been found expressing up-regulation in nonnervous system disease. Alpha-synuclein has some effects on signal transmission, neural plasticity, Cell differentiation and viability.

作者黄炎苏琦

机构地区南华大学肿瘤研究所

出处《国际病理科学与临床杂志》 CAS 2006年第5期420-423,共4页 Journal of International Pathology and Clinical Medicine

关键词 α-synuclein蛋白结构功能 alpha-synuclein structure function

分类号 Q26 [生物学—细胞生物学]

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1Maroteaux L, Campanelli J T, Scheller R H. Synuclein: a neuronspecific protein localized to the nucleus and presynaptic nerve terminal [J]. J Neurosci, 1988, 8(8) :2804-2815.
2Ueda K, Fukushima H, Masliah E, et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer's disease[J]. Proc Natl Acad Sci USA, 1993, 90(23):11282-11286.
3Braak H, Tredici K D, Gai W P, et al. Alpha-synuclein is not a requisite component of synaptic boutons in the adult human central nervous system [J]. J Chem Neuroanat, 2000, 20(3 -4):245-252.
4Ellis C E, Schwartzberg P L, Gilder T L, et al. Alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases[J]. J Biol Chem, 2001, 276(6) :3879-3884.
5Jo E, McLaurin J, Yip C M, et al. Alpha-synuclein membrane interactions and lipid specificity [J]. J Biol Chem, 2000, 275(44) : 34328-34334.
6Hashimoto M, Takenouchi T, Rockenstein E, et al. Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extraeellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease [ J ]. J Neurochem, 2003, 85 (6) : 1468-1479.
7Nakamura T, Yamashita H, Takahashi T, et al. Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125 [ J]. Biothem Biophys Res Commun, 2001, 208 (4) :1085-1092.
8Jenco J M, Rawlingson A, Daniels B, et al, Regulation of phospholipaseD2 : selective inhibition of mammalian phospholipase D isoenzymes by alpha-and beta-synucleins [ J ]. Biochemistry,1998, 37: 4901-4909.
9Osterova N, Petrucelli L, Farter M, et al. Alpha-Synuclein shares physical and functional homology with 14-3-3 proteins[ J]. J Neurosci, 1995, 19(14):5782-5791.
10Jensen P H, Hager H, Nielsen M S, et al. Alpha-Synuelein binds to tau and stimulates the protein kinase A-eatalyazed tau phosphorylation of sefine residues 262 and 356 [ J]. J Biol Cbem, 1999,274(36) : 25481-25489.

1王群群,答亮,王翼飞.α-synuclein蛋白与A-β肽和β-synuclein蛋白相互作用位点的预测[J].上海大学学报（自然科学版）,2012,18(2):178-182.
2周小爽,李晔,白洁.MicroRNAs与帕金森氏病[J].生命科学,2013,25(1):54-57. 被引量：1
3陈忠,苏维埃.豌豆中可与Gro EL抗体发生免疫学反应的热激诱导蛋白[J].Acta Botanica Sinica,1998,40(10):933-938. 被引量：4
4于珊珊,李艳,陈冠军,刘巍峰.酿酒酵母中α-synuclein蛋白聚集诱导的细胞毒性的研究[J].微生物学通报,2008,35(2):249-255.
5黄银霞,韩俊,张晓光,姚海兰,王小凡,张瑾,张宝云,董小平.帕金森病相关蛋白α-共核蛋白的可溶性表达、纯化及抗体制备[J].中国老年学杂志,2006,26(2):201-204. 被引量：1
6曹赞霞,王吉华.促进或抑制α-synuclein蛋白异常聚集的相互作用蛋白质[J].生物物理学报,2010,26(9):783-789. 被引量：4
7黄银霞,韩俊,韩露,董辰方,高晨,王小凡,周伟,董小平.α-Synuclein与14-3-3蛋白在体外分子间相互作用的鉴定[J].中国生物化学与分子生物学报,2007,23(6):469-473. 被引量：2
8陈曦,时国庆,钟广蓉,陈娟,林森,孙清.三苯基锡对神经细胞蛋白酶体活性与相关蛋白水平的影响[J].科学通报,2009,54(19):2962-2966.
9王丹晨,于珊珊,刘巍峰,陈冠军.α-Synuclein蛋白聚集状态与帕金森病形成[J].中国生物化学与分子生物学报,2006,22(8):615-620. 被引量：7
10陈敏.破译生命之书[J].科学新闻,2000,0(28):20-20.

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α-共核蛋白的结构和功能研究进展

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