肺炎衣原体感染致血管平滑肌细胞的改变

Chlamydia pneumoniae infection inducing vascular smooth muscle cell change in function and morphology

肺炎衣原体感染是动脉粥样硬化发生的重要危险因素。肺炎衣原体可以感染血管壁内皮细胞、平滑肌细胞、单核细胞/巨噬细胞,并与这些细胞之间相互作用,影响这些细胞的形态与功能,从而参与动脉粥样硬化发生发展。在动脉粥样硬化发病机制中,平滑肌细胞形态功能的变化与动脉粥样硬化密切相关,肺炎衣原体能够感染平滑肌细胞,影响平滑肌细胞在血管内的生理生化特征,促进动脉粥样硬化的发展过程。

Chlamydia pneumoniae（Cpn） infection is one of proatherosclerosis risk factors. Cpn may infect endothelial cells, smooth muscle cells, and monocytes/macrophages in the vascular wall. Cpn influences these cells morphology and function through interacting with these cells, which participate in atherogenesis. Among the pathophysiology of atherogenesis, the change of SMCs morphology and function is close related with atherosclerosis. Cpn may infect SMCs and influence the physiological and biochemistrical characters of SMCs, and promote atherosclerosis to develop.