MRP1/CD9在膀胱癌组织中的表达及意义

Expression and significance of MRP1/CD9 in bladder carcinoma

目的探讨M RP 1/CD 9在膀胱癌组织的表达及其临床意义。方法用免疫组化SP法检测M RP 1/CD 9在膀胱癌组织和正常膀胱黏膜组织中的表达。结果正常膀胱组织中M RP 1/CD 9均为阳性。膀胱癌组织中M RP 1/CD 9表达降低,且与病理分期呈负相关,与临床分期无相关性。结论在膀胱癌组织中M RP 1/CD 9表达降低,可能与膀胱癌的发展有关。其降低程度可以作为评估膀胱癌恶性程度的一个重要指标。

[Objective] To investigate the expression and significance of MRP1/CD9 in bladder carcinoma. [Method] Immunohistochemistry was used to detect the MRP1/CD9 expression in 52 cases with bladder carcinoma and 10 cases of normal bladder tissues. [Result] Positive expression of MRP1/CD9 was detected in 10 （10/10） normal tissue and 27 （27/52） cases of bladder carcinomas. Negative correlation was found between MRP1/CD9 protein expression and pathological grade （ P 〈0.05）. There was no statistical significance between MRP1/CD9 expression and clinical tumor stage （P 〉0.05）. [Conclusion] MRP1/D9 expression is downregulated in bladder carcinoma and is possible to correlate with progression of bladder carrinma, MRP1/CD9 expression down-regulation degree may be used as an inder for bladder carcinoma malignance.