摘要
高血压大鼠记忆障碍及海马Ｍ受体亚型的变化彭凯润１赵树进２张幸运１石尚金１（广州军区广州总医院１．神经内科，２．药理科，广州５１００１０）ＨｙｐｅｒｔｅｎｓｉｏｎＩｎｄｕｃｉｎｇＡｍｎｅｓｉａａｎｄＣｈａｎｇｅｓｏｆＭｕｓｃａｒｉｎｉｃＲｅｃｅｐｔｏｒ...
Aim\ To explore
the effects of hypertension on amnesia and its mechanism.\ Methods\
In renovascular hypertensive rat(RHR) amnesia was evaluated by water
maze and changes in content of M 1, M 2 receptors in hippocampus was
assessed by ELISA methods. Results\ There was serious amnesia in
RHR, and the content of M 1 receptors in hippocampus decreased
significantly.\ Conclusion\ Hypertension can induce demental,which
might be due to the changes in content of M receptor subtypes in
hippocampus.
出处
《高血压杂志》
CSCD
1996年第4期255-256,共2页
Chinese Journal of Hypertension
关键词
高血压
痴呆
肾血管性
M受体
hypertension
demental
muscarinic receptor
subtypes
renovascular hypertensive rat
