补气活血益肾法治疗局灶节段肾小球硬化43例临床观察

Treatment of Focal Segmental Glomerulosclerosis by Buqi Huoxue and Yishen Therapy: A Clinical Observation of 43 Cases

目的：观察补气活血益肾法治疗局灶节段肾小球硬化(FSGS)的临床疗效。方法：对经正规激素治疗无效且经肾穿刺病理确诊的FSGS患者43例,采用补气活血益肾法(由黄芪、当归、川芎、桃仁、红花、赤芍、地龙、女贞子、旱莲草等组成)治疗,疗程为3月。主要观察临床疗效及治疗前后尿蛋白、24小时尿蛋白定量、血清白蛋白及胆固醇等指标的变化。结果：临床控制1例,显效22例,有效12例,无效8例,总有效率为81．40%。治疗后24小时尿蛋白定量、血清白蛋白及血脂均明显改善,与治疗前比较,差异均有非常显著性意义(P＜0．01)。结论：采用补气活血益肾法治疗FSGS疗效显著,并通过对蛋白尿、白蛋白、胆固醇的调节,延缓FSGS病程。

Objective:To observe the clinical effect of Buqi Huoxue and Yishen therapy (BHYT) for focal segmental glomerulosclerosis (FSGS). Methods:43 cases of FSGS were confirmed by kidney biopsy which were ineffective by routine hormone treatment and were treated by BHYT (composed of Radix Astragali,Radix Angefieae Sinensis,Rhizoma Chuanxiong,Semen Persicae,Flos Carthami,Radix Paeoniae Rubra, Pheretima,Fructus Ligustri Lucidi,Herba Eeliptae,etc.).3 months con- stituted the course of treatment.The clinical effect,urinary protein,24h urinary protein quantitative test,albumin and cholesterol were observed be- fore and after treatment.Results:1 case was controlled clinically,22 cases markedly effective,12 cases effective and 8 cases ineffective,the to- tal effective rate being 81.40%.After treatment,24h quantitative urinary protein,serum albumin and blood fat were markedly improved than before treatment (P＜0.01).Conclusion:BHYT exerts marked effect for FSCS and delays the progress of FSGS by regulating urinary protein,albumin and cholesterol.