EB病毒潜在膜蛋白在胃贲门腺癌组织中的表达

Expression of Epstein-Barr Virus Latent Membrane Protein-1 in Cardial Adenocarcinoma Tissue

应用Ｓ－Ｐ免疫组化方法对８０例贲门腺癌进行抗ＥＢ病毒（ＥＢＶ）潜在膜蛋白（ＬＭＰ－１）单克隆抗体的检测。结果显示：癌组织阳性１４例（１７．５％），阳性部位主要位于癌细胞膜和胞浆内。对ＥＢＶ感染病例的形态学特征进行描述，并讨论ＥＢＶ与癌发生的联系。

cases of cardial adenocarcinoma were detected by using the immunohistochemical S-P method to determine the expression of Epstein-Barr virus(EBV) latent membrane protein-1(LMP-1). The results showed 14 cases(17. 5%) of cardial adenocarcinoma were EBV LMP-1 positive, mainly on the cell surface and within the cytoplasm. Some morphological features were described, and the relationship between EBV and carcinogenesis was discussed.