消水Ⅱ号经人体透皮吸收药时关系

Determination on Percutaneous Absorption of Borneol,in the Ⅱ recipe of Eliminating Effusion

探讨消水Ⅱ号在人体的透皮吸收行为和药时关系。以冰片作为消水Ⅱ号在癌性胸腹水患者胸腹部敷药后不同时间的胸腹水液中的冰片含量。结果:在给药后2 h的患者胸腹水中测出了冰片的含量为2 3 6 ng/ml,随着时间延长,胸腹水中的冰片含量增加,在敷药3 6 h测出胸腹水中的冰片含量最高,达2 4 2 5 ng/ml,以后则逐渐降低。结论:消水Ⅱ号可部分在人体透皮吸收,其在人体的透皮吸收具有缓释、长效的特点。

To study percutaneous absorption of borneol in human＇s body, the main ingredient of the Ⅱ recipe of elininating effusion, the concentration of borneol in biological sample which was taken from different patient＇s malignant effusion at different time was determined by gas chromatography. The results showed that the borneol was 236 ng/ml in 2 hour＇s effusion, then the concentration of borneol increased slowly, 36 h later borneol reached the highest value 2425 ng/ml in effusion, and afterwards it decreased gradualy. The main ingredient of the Ⅱ recipe of eliminating effusion-borneol can be absorbed via human＇s skin, it＇s concentration in effusion is raised slowly, and is kept for a long time in it.