环丙沙星治疗急性细菌性痢疾的临床对照试验

Clinincal Comparison Study on the Treatment of Bacterial Dysentery by Ciprofloxacin

为比较环丙沙星与诺氟沙星治疗急性细性痢疾的疗效,将105例患者分为两组进行临床对照试验.试验组55例,给予环丙沙星口服(儿童30mg/(kg·d),tid,成人0.5g,bid或tid);对照组50例,给予诺氟沙星口服(儿童15～20mg/(kg·d),tid;成人0.2g,tid).两组治愈率和好转率分别为87.3%、12.7%和46.0%、54.0%(均P<0.01);治疗3d后细菌培养阴转率分别为87.3%和63.0%(P<0.01);治愈者疗程分别为4.27d和5.74d(P<0.01).试验结果显示环丙沙星对急性细菌性痢疾的疗效优于诺氟沙星.

To compare the effects of ciprofolxacin and norfolxacin on acute bacterial dysentery, 105 patients were divided into two groups. The patients in experimental group received ciprofloxacin orally (30 mg/kg ?d, for children and 0.5g, bid or tid for adults). The patients in control group were given norfloxacin orally (15-20 mg/kg昫 for children and 0.2g, tid for adults). The cure rates and recovery rates were 87.3% and 12.7% in experimental group and 46.0% and 54. % in control group (P<0.01). The the results of bacterial culturing turned to negative in 87.3% in experimental group and 63.0% in control group (P<0. 01). Our results showed that effect of ciprofloxacin on acute bacterial dysentery was better than that of norfloxacin.