使用ADC值评估正常及退变腰椎间盘的初步研究

Assessment of apparent diffusion coefficient values in normal and degenerated intervertebral lumbar disks: preliminary study

目的:使用平均表观弥散系数(apparent diffusion coefficient,ADC)值可反映成人腰椎间盘中的水分子运动,探讨椎间盘ADC值和MR表现是否有相关性。方法:对28例患者及22名志愿者进行腰椎的MR弥散加权成像,测量每个椎间盘的ADC值。根据矢状位T2WI的MR表现,将椎间盘分为正常组和退变组。对比正常和退变椎间盘的平均ADC值,并对部位进行相关研究。结果:总计50名参与者中除3例因伪影明显未行ADC值测量外,余47例均成功行DWI及ADC值测量。正常和退变椎间盘的平均ADC值分别为2.32±0.54(×10-3mm2/s)和1.87±0.42(×10-3mm2/s)。ADC值与部位有明显的统计学相关性。结论:对比正常腰椎间盘,退变椎间盘的ADC值有明显的减低。且邻近骶尾部的椎间盘较头侧椎间盘的ADC值低。

Objective：To reflect the diffusibility of water in lumbar disks in adults by using the mean apparent diffusion coefficient （ADC） values and to determine if there was a relationship between ADC values and magnetic resonance findings of disks. Methods： Diffusion weighted imaging of lumbar spine was performed in 28 patients and 22 volunteers. ADC values of each disk were measured. According to the sagittal T2-weigted images, all disks were graded into normal and degeneration. Mean ADC values of normal disks were compared with those of degenerated disks and were correlated with anatomic location. Results： The calculation of ADC values was possible in 47 of 50 participants. ADC values could not be calculated in three participants because of poor signal-to-noise and too great .artifact. The mean ADC values of normal and degenerated disk were 2.32 × 10^-3 ± 0.54（mm^2/s） and 1.87×10^-3 ±0.42（mm^2/s） respectively. There was significant correlation between mean ADC values and anatomic location （ P 〈 0.05）. Conclusion：Comparing with ADC values of normal disk, a statistically significant decrease was displayed in tbe degenerated lumbar, disks, with lower ADC values seen in more caudal disks.