乳腺癌乏氧诱导因子-1α(HIF-1α)与雌激素受体表达的关系

CLINICAL CORRELATION BETWEEN EXPRESSION OF HYPOXIA INDUCIBLE FACTOR-1α(HIF-1α)AND ESTROGEN RECEPTOR IN BREAST CARCINOMA

目的探讨乳腺癌乏氧诱导因子-1α(hypoxia induci blefactor-1α,HIF-1α)与雌激素受体(ER)表达的关系。方法利用免疫组织化学方法在42例乳腺癌组织中进行HIF-1α染色,并与ER表达情况及其他临床病理资料进行相关性分析。结果乳腺癌组织中HIF-1α阳性表达率为54.76%,ER表达阳性率为66.67%(28/42)。ER表达率在HIF-1α阳性者中为56.52%,HIF-1α阴性者中为78.95%,P=0.125。而在细胞水平上,ER在HIF-1α阳性者和阴性者中的表达量积分,分别为2.96±1.97、5.11±2.58,t=3.06(P=0.004),Spearman等级分析,r=-0.49(P=0.003)。另外,HIF-1α表达除常见于绝经后患者外,与肿瘤大小、病理类型、孕激素受体、腋窝淋巴结转移、Ki67、C-erbB-2表达均无显著相关。结论乳腺癌组织中HIF-1α表达可能参与了ER表达下调的机制。

Objective To investigate the corre1αtion between expression of HIF-1α and estrogen receptor in breast carcinoma. Methods HIF-1α was stained by immunohistoehemistry in histologie sections of specimens from 42 breast carcinoma cases and correlated with estrogen receptor （ER） status and the other clinico-pathological characteristics. Results HIF-1α and ER staining was respectively observed in 54. 76% and 66.67M patients of breast carcinoma. 56.52% HIF-1α positive patients expressed ER, but 78.95% HIF-1α negative patients expressed ER, P=0. 125. However, at the microscopic level, HIF-1α score was inversely re1αted to ER score, r= -0.49, P=0. 003. ER score was much lower in HIF-1α positive cases （2.96±1.97） than in the negative counterparts （5. 11±2. 58）, P=0. 004. Except that HIF-1α expression was more often seen in postmenopausal patients, it was not re1αted to any other clinico-pathological characteristics, such as tumor size, histology, progesterone receptor, axillary lymph node metastasis, or expression of both Ki67 and C-erbB2. Conclusion HIF-1α may play a role in the mechanism of ER down-regulation in breast carcinoma.