腹膜透析对重症急性胰腺炎大鼠肾损害的保护作用

Protective effect of peritoneal dialysis on renal damage following acute severe pancreatitis in rat

目的探讨腹膜透析(PD)对重症急性胰腺炎(SAP)大鼠肾损害的保护作用并探讨可能的机制。方法SD大鼠72只随机分为对照组(24只)、SAP组(24只)和PD组(24只),观察各组血清前列腺素(TXA2/6-K-PGF1a)及内皮素(ET-1)水平和肾脏病理变化。结果SAP组和PD组血清ET-1水平较对照组明显升高,同时段SAP组与PD组比较,PD组水平明显降低;SAP组和PD组血清TXA2/6-K-PGF1a水平较对照组明显升高,同时段SAP组与PD组比较,PD组水平明显降低。PD组大鼠肾病理损害较SAP组明显减轻。结论血液流变异常参与SAP肾损害的发生,早期进行PD治疗对SAP大鼠肾有保护作用,其可能的机制是改善微循环、清除炎症介质等。

Objective To study the protective effect of peritoneal dialysis （PD） on renal damage following severe acute pancreatitis （SAP） in rat. Methods SD rats were randomly divided into three groups： the control group （ n = 24）, the SAP group （ n = 24） and PD group （ n = 24）. The blood TXA2/6-K-PGF1a and ET-1 were measured. The pathological alterations of kidneys were recorded in each group. Results Plasma levels of TXA2/6-K-PGF1a and ET-1 were significantly higher in SAP group and SAP with PD group than in control group, and at the same time, they were significantly lower in PD group than in SAP group. The scoring of damages in kidneys were less severe in PD group. Conclusion The renal damage following SAP is caused by hemorrheological disorder. Early therapy with PD can protect against renal damages in SAP rats.