右旋糖酐铁治疗血液透析患者重度肾性贫血

Therapeutic Effect of Iron Dextran Injection in Treatment of the Patients with Serious Renal Anemia Induced by Hemodialysis

目的:观察右旋糖酐铁注射液治疗维持性血液透析(血透)患者肾性贫血的疗效。方法:46例维持性血透患者,每周血液透析3次,每次4h。随机分为注射右旋糖酐氢氧化铁组(21例)与口服琥珀酸亚铁组(25例),检测治疗前后血清铁指标、红细胞相关指标及生化指标。结果:10次血透后两组Hb,Hct,血清铁蛋白(SF)与转铁蛋白饱和度(TSAT)均较治疗前显著升高,且静脉组明显高于口服组(P<0．01)。结论:静脉注射右旋糖酐氢氧化铁可有效纠正维持性血透患者的铁缺乏、提高铁利用率及重组红细胞生成素的治疗效果。

Objective： To investigate the therapeutic effect of intravenous therapy with iron dextran injection on hemodialysis patients with serious renal anemia. Method： Forty-six patients of uremia for hemodialysis were divided into two groups randomly, Twentyfive patients who took ferrous succinate tablets were regarded as the controlled. The other 21 patients who received intravenous therapy with iron dextran injection were regarded as the treated group. The serum iron index, correlated red cell index and biochemical index were checked in before and after treatment. Result： Hemoglobin（ Hb）, heamatocrit（ Hct）, transferrinsaturation（TSAT） and serum ferritin（SF） levels were significantly higher than that before the thrapy（ P 〈 0, 01 ）in two groups after hemodialysis 10 times, but Hb, Hct, TSAT, SF were significantly higher after the therapy in the treated group than that in the controlled（ P 〈 0.01 ）. Conclusion： Intravenous therapy with iron dextran injection can quickly improve anemia in patients with hemodialysis, raise iron availability and therapeutic efficacy of rHuEPO.