Ki-67在眼眶淋巴组织增生病中的临床意义

The Study and Significance of Ki-67 on Orbital Lymphoproliferative Diseases

目的:探讨Ki-67在眼眶淋巴组织增生病良恶性诊断中的价值。方法:采用Ki-67单克隆抗体,应用免疫组织化学方法对77例眼眶淋巴组织增生病进行检测。结果:炎性假瘤无阳性染色,反应性淋巴组织增生以核仁着色多见。不典型淋巴组织增生阳性细胞除核仁着色外,亦可见到细胞核及胞浆的着色。而恶性淋巴瘤多数为细胞核着色,亦见胞浆着色。阳性细胞分布为弥漫或聚集状,有时亦见内皮细胞着色。反应性淋巴组织增生阳性指数为(3.751±2.513)%,不典型淋巴组织增生阳性指数为(4.274±2.124)%,恶性淋巴瘤阳性指数为(40.94±25.67)%,反应性淋巴组织增生与不典型淋巴组织增生之间差别无统计学意义,而与恶性淋巴瘤比较差别有统计学意义(P<0.05)。结论:Ki-67可以鉴别眼眶淋巴组织增生病的良恶性及指导临床治疗。

Objective： To investigate the diagnostic value of Ki-67 in differentiating benign from malignance of orbital lymphoproliferative diseases. Methods： Seventy-seven patients with orbital lymphoproliferative disease were studied by immunohistochemical methods using Ki-67 monoclonal antibody. Results： There was no Ki-67 positive staining in inflammatory pseudotumor, reactive lymphoid lyperplasia had a majority of nucleolus staining. Besides nucleolus staining nucleus and ky toplasm staining was seen too in tle atypiall lymphoid hyper plasis, Howeaev, there was nucleolus stainoing in the malignant lymphoma and kytoplasm staining was seen either, Positive cell distribution was coneentrateel or disseminated, sometines, there was a lot of endothelial cell staining, the positive figure of reactive lymphoid hyperplasia was （3,751±2.513）%, the positive figure of atypical lymphoid hyperplasia was （4.274±2.124）% ,the positive figure of malignant lymphoma was （40.94 ± 25.67）%,the difference between reactive lymphoid hyperplasia and atypical lymphoid hyperplasial was not statistical,however, reactive lymphoid hyperplasia had a statistical difference compared with malignant lymphoma （P 〈 0.05）, Conclusion： Ki-67 can be used to differentiate benign from malignance of orbital lymphoproliferative diseases and direct a curative programme.