摘要
目的确定秋水仙碱滴丸的成型工艺。方法以滴丸的成型外观和成丸的重量差异为评价指标,采用正交试验法研究滴丸成型工艺的较优工艺条件。结果工艺条件为:药物∶聚乙二醇6000质量比为1∶10,药料温度60℃,冷却剂的温度10℃,冷却柱长90 cm。结论本文所确定的成型工艺合理,制备得到的滴丸均符合中国药典质量标准。
Objective To optimize the preparation process of colchicine drop pills. Methods Hardness, appearance and stickiness were used as the quality indexes. The preparation process was optimized by orthogonal design. Results The favorable conditions were as follows：the ratio of colchicine to PEG6000 was 1： 10, the temperature of the mixture was 60 ℃ ,the temperature of the refrigerant was 10 ℃, and the length of the refrigerant column was 90 cm. Conclusion The shaping technics of the dropping pills was reasonable.
出处
《广东药学院学报》
CAS
2006年第5期477-478,485,共3页
Academic Journal of Guangdong College of Pharmacy
关键词
秋水仙碱滴丸
成型工艺
正交试验
colchicine
dropping pills
shaping process
orthogonal design
