不同处方5-Fu胃粘附缓释片的溶出度考察

Dissolution of 5-Fu Sustained Releasing Tablets under Different Formulas

目的:考察不同处方5-Fu胃粘附缓释片剂的溶出度。方法:采用浆法,以0．1mol·L-1盐酸溶液为溶出递质,转速为100r·min-1,温度为(37．0±0．5)℃,利用紫外分光光度法在265nm的波长处测定,进行累积溶出百分率计算。结果:Carbopol 980 PNF、HPMC、ph101、乳糖四种赋形剂的比例不同,其溶出百分率亦存在差异。结论:不同处方的5-Fu胃粘附缓释片的体外溶出度存在显著差异,应继续对处方进行优化,使6h累积释放率达100％。

This paper studies the dissolution of 5-Fu sustained releasing tablets under different formulas. The paddle method is used. Hydrochloric acid with a concentration of 0.1mol/L is taken as the solvent. The rotational speed is set at 100r/ min, and the temperature 37.0±0.5℃. The absorptivity is registered with an ultraviolet spectrophotometer at a wavelength of 265nm. It is found that dissolution readouts are changed for different concentrations of HPMC, ph101, lactose, and Carbopol 980 PNF. The zero-order kinetic equation, first-order kinetic equation, and Higuchi equation are used to measure the release behavior in vitro. Of them, the combination of Carbopol 980 PNF, HPMC, lactose, and ph101 at a proportion of 3：2：5：5 makes the highest dissolution, which reaches a percentage of 86 six hours after release. It is concluded that there are significant differences between different 5-Fu sustained releasing tablets, in the context of dissolution. It is suggested that formulas shall be further optimized to make the dissolution a full 100%.