腹腔加静脉化疗防治卵巢癌术后复发的临床疗效观察

Efficacy of intraperitioneal perfusion chemotherapy combined with intravenous chemotherapy in prevention of recurrence of ovarian cancer

目的评估腹腔加静脉化疗对卵巢癌患者术后复发的影响。方法将患者随机分为腹腔加静脉化疗组(治疗组)22例和单纯静脉化疗组(对照组)20例。于术后1个月内开始进行腹腔加静脉化疗及单纯静脉化疗,对比两组1,3年生存率及复发率。结果治疗组的1,3年及总生存率均高于对照组,差异有显著性(P=0.0481);治疗组复发率低于对照组(P=0.032)。治疗组消化道的副反应发生率低于对照组(P=0.032)。结论腹腔加静脉化疗可有效提高卵巢癌术后患者的生存率,减少复发率。

Objective To study the effectiveness of intraperitioneal perfusion chemotherapy combined with intravenous chemotherapy in prevention of recurrence of ovarian cancer. Methods Forty-four patients were treated with intraperitioneal perfusion chemotherapy combined with intravenous chemotherapy （combined treatment group） or intravenous chemotherapy alone （control group）1 month after operation. The 1-,3-year survival rates of two groups were compared. Results The 1-,3-year survival rates in combined treatment group were higher than those in control group. Meanwhile, the recurrence rate in combined treatment group was lower than that in control group, and the digestive tract reaction was also lower（ P 〈 0.05 ）. Conclusion Intraperitoneal perfusion chemotherapy combined with intravenous chemotherapy is effective to control the post-operative recurrence of ovarian cancer.