热疗配合化疗治疗鼻咽癌颈部淋巴结转移的临床观察

Clinical evaluation of heat therapy combined with chemotherapy in treatment of nasopharyngeal carcinoma with metastatic foci in cervical lymph nodes

目的初步探讨热疗配合化疗(热化疗)治疗鼻咽癌颈部淋巴结转移患者的近期疗效。方法选择我科收治的中晚期鼻咽癌并颈淋巴结转移患者36例,按患者入院先后次序以及有否热疗禁忌证随机分两组,治疗组20例给予2周期的热化疗,对照组16例予单纯化疗,观察两组患者的肿瘤转移灶的缓解率、生活质量等。结果治疗组CR 9例,PR 10例,SD 1例;对照组CR 4例,PR7例,SD 5例。结论热化疗在鼻咽癌颈部淋巴结转移的辅助性化疗中应用简便且安全,有较好的近期疗效,能改善患者的生存质量。

Objective To evaluate short-term efficacy of the method of heat therapy combined with chemotherapy（heat chemotherapy） in treating nasopharyngeal carcinoma with metastatic foci in cervical lymph nodes. Methods Thirty-six patients with nasopharyngeal carcinoma with metastatic loci in cervical lymph nodes were randomly divided into 2 groups ：20 patients in treatment group were treated with heat therapy and chemotherapy for two cycles and 16 patients in control group were treated with chemotherapy alone. The local response rates and living quality in 2 groups were observed. Results Of the 20 cases in treatment group,9 were CR,10 PR and 1 SD. Of the 16 cases in control group,4 were CR, 7 PR and 5 SD. Conclusions Heat chemotherapy for nasopharyngeal carcinoma with metastatic foci in cervical lymph nodes is simple and safe. It showed good short-term curative effects and improved the living quality of patients.