天晴日安治疗化疗后恶心呕吐的临床研究

Efficacy of azasetron hydrochloride in the treatment of nausea and vomiting induced by chemotherapy

目的观察选择性5-HT3受体拮抗剂———盐酸阿扎司琼氯化钠(天晴日安)预防化疗所致的消化道反应的临床疗效。方法随机选择52例化疗患者,治疗组26例,天晴日安10 mg,化疗前30 m in静注;对照组26例,盐酸恩丹西酮8 mg,静推,化疗前后15 m in应用。结果天晴日安对急性恶心的有效率为96.2%,恩丹西酮为92.3%;天晴日安对急性呕吐的有效率为100%,恩丹西酮为88.5%。天晴日安组便秘发生率42.3%,恩丹西酮组57.7%。结论天晴日安对化疗所致恶心呕吐具有良好的治疗作用,副作用小,且无锥体外系症状。

Objective To evaluate the efficacy of azastron hydrochloride in prevention of naesea and vomiting caused by cancer chemotherapy. Method Fifty-two patients were randomized to treament group（26 cases） and control group（26 cases）. Results The rates of nausea-free were 96.2% and 92.3%, the rates of vomiting-free were 100% and 88.5% ,and the rates of constipation were 42.3% and 57.7% in azastron and ondansetron groups respectively. Conclusion Azastron is effective in treatment of nausea and vomiting induced by chemotherapy, and its side effects are mild.