摘要
目的观察大鼠30%Ⅲ度烧伤后趋化因子NAP-2和PF-4在大鼠骨髓巨核细胞的表达变化情况。方法采用免疫组织细胞化学的方法观察烧伤后24h和15d NAP-2和PF-4表达情况。结果大鼠烧伤后24h骨髓巨核细胞特异分泌的趋化因子NAP-2和PF-4明显低于正常组,烧伤后15d巨核细胞表达NAP-2和PF-4较烧伤后24h恢复,但仍低于正常对照组。结论严重烧伤可以导致大鼠骨髓巨核细胞分泌特异趋化因子NAP-2和PF-4的能力减退。
Objective To investigate the expression of NAP-2 and PF-4 in bone marrow megakaryocytes in rats after burns （30% TBSA, full thickness burn） and to analyze the mechanism of megakaryocytophagia. Methods Expression of NAP-2 and PF-4 of bone marrow megakaryocytes in rats after burns （30%TBSA, full thickness burn） was detected by immunohistochemistry. Results The results of immunohistochemistry showed that the expression of NAP-2 and PF-4 in megakaryocytes after burns was lower than normal. Conclusion Megakaryocytes were injured after burns and showed low expression of NAP-2 and PF-4 which induced neutrophils enter the injured mgakaryocytes . megakaryocytophagia may be assotiated with other factors.
出处
《重庆医学》
CAS
CSCD
2006年第19期1754-1756,共3页
Chongqing medicine
基金
国家自然科学基金资助重点项目(30230360)
