肺良性肌上皮瘤临床病理观察

Benign myoepithelioma of lung: a case report and review of literature

目的报道1例肺的良性肌上皮瘤,并复习文献,对其临床病理特点及鉴别诊断进行讨论。方法对手术切除的肺及其肿瘤进行常规病理检查,HE及免疫组化(S-100、p63、CK、SMA、GFAP)染色,光镜检查。结果患者女性,58岁。左肺上叶舌段良性肌上皮瘤,突入支气管腔内,大小为1·8cm×1·5cm×1·2cm,瘤组织呈不规则片块状,由卵圆形细胞、透明细胞及少量梭形细胞构成,免疫组化显示瘤组织S-100、p63和CK(+)。结论肺良性肌上皮瘤是一种非常罕见的肿瘤,根据组织形态、结合免疫组化及电镜检查,可作出明确诊断及鉴别诊断。

Objective To describe a benign myoepithelioma of the lung, reviewe the literature, and discuss chnical pathology and differential diagnosis, Methods Routine pathologic study, HE, immunohistochemical staining （S-100, p63, CK, SMA, GFAP） and light microscopy were used to analyze a resectied lung tumor tissue. Results A 58-year-old female patient was found a benign myoepithelioma measured 1.8 cm × 1.5 cm × 1.2 cm in the lingual segment portion of the left upper lobe, extensded to the bronchial lumen. Tumor tissue was irregular sheets and composed of the oval cells, clear cells and a few of the fusiform cells Immunohistochemistry showed tumor tissue was positive reaction of S-100, p63, CK, SMA, GFAP. Conclusion Benign myoepithelioma was a rare tumor In the lung. According to histomorpholgy, immunohistochemistry and electron microscopy, we might obtain diagnosis and differential diagnosis.