卫氏与斯氏并殖吸虫在实验动物体内分布的比较观察

COMPARATIVE OBSERVATION OF DISTRIBUTION OF PARAGONIMUS WESTERMANI AND PAGUMOGONIMUS SKRJABINI IN EXPERIMENTAL ANIMALS

目的比较两种主要对人体致病的肺吸虫在实验动物肺内与肺外(胸、腹腔)的分布,为临床诊断及药物治疗提供参考。方法粪检肺吸虫卵阴性的猫犬分别经口感染卫氏并殖吸虫(P.W)与斯氏并殖吸虫(P.S)囊蚴,饲养3个月后粪检肺吸虫卵阳性时对犬、猫进行解剖,观察与统计内肺外虫数。结果猫犬解剖所获得P.W与P.S成虫均以左、右肺下叶寄生成虫数最多,猫、犬感染P.W后检获肺外期与左、右肺的童虫数均无显著性差异(P>0.05)。猫感染P.S后所检获肺外期童虫数与左、右肺的童虫数有显著性差异(P<0.05),而犬感染P.S所检获肺外期童虫数与左、右肺的童虫数有高度显著性差异(P<0.01)。猫感染P.W与P.S囊蚴后虫体平均回收率为41.84%,39.85%;犬感染P.W与P.S囊蚴后虫体平均回收率分别为47.44%,24.57%。经统计学处理猫感染两种虫体回收率显著高于犬(P<0.05)。结论两种肺吸虫在实验动物犬、猫肺部的分布均以左、右肺下叶寄生成虫数最多,猫犬感染P.S所检获的肺外期童虫数与检获左、右肺内的童虫数分别为有显著性差异(P<0.05)与高度显著性差异(P<0.01),猫感染虫体的回收率明显高于犬。

Objective To compare distribution of two major pathogenic lung flukes in lungs and the other places out of lungs （ chest, abdominal cavity） of experimental animals, in order to offer suggestion for clinical diagnosis and therapy. Methods The dogs and cats were infected with metacercarias of Paragonimus westermani （P. W）, Pagumogonimus skrjabini （P. S） respectively through mouth. The animals when the eggs were found in their feces were killed, 3 months after infection, and the number of adults were counted and analyzed. Results The number of adults found from left and right lower lobe lungs of cats and dogs infected with P. W and P. S were most. The number of pre-adults collected from the cats and dogs infected with P. W had no statistically difference by com- paring left and right lungs with the other place out of lungs （ P 〉 0.05 ）, but that from cats infected with P. S had statistically difference （ P 〈 0.05 ）, and that from dogs infected with P. S had remarkably statistically difference （ P 〈0.01 ）. The average recovery rates of adult worms of P. W and P. S were 41.84% , 39.85% from infected cats, and that from dogs were 47.44% , 24.57% on average, respectively. The recovery rates of two lung flukes from cats were markedly higher than that from dogs （ P 〈 0.05 ）. Conclusion The recovery rates of two lung flukes from cats were markedly higher than that from dogs.