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深部曲霉菌感染实验室诊断进展 被引量：5

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摘要 深部曲霉菌感染是引起临床免疫低下患者感染及病死较严重的条件致病菌之一。传统的实验室诊断存在一定的弊端。现从血清学和分子生物学两方面对曲霉菌诊断的现状及优缺点,以及Real-timePCR诊断的发展前景及存在的问题作一综述。
作者 张梦宇 郑磊 王前
机构地区 南方医科大学南方医院检验医学中心
出处 《国际检验医学杂志》 CAS 2006年第10期913-915,共3页 International Journal of Laboratory Medicine
关键词 曲霉菌病 曲霉菌属 实验室技术和方法
分类号 R519 [医药卫生—内科学]
  • 相关文献

参考文献11

  • 1Pryce TM, Kay ID, Palladino S, et al. Real-time automated poly-merase chain reaction (PCR) to detect Candida albicans and Aspergillus fumigatus DNA in whole blood from high-risk patients. Diagn Microbiol Infect Dis, 2003, 47(3):487-496.
  • 2Maertens J, Van-Eldere J, Verhaegen J, et al. Use of circulating galactomannan screening for early diagnosis of invasive aspergillosis in allogeneic stem cell transplant recipients. J Infect Dis, 2002, 186(9)~ 1297-1306.
  • 3Mennink-Kersten MA, Donnelly JP, Verweij PE. Detection of circulating galactomannan for the diagnosis and management of invasive aspergillosis. Lancet Infect Dis, 2004, 4(6):349-357.
  • 4Marr KA, Balajee SA, McI.aughlin I., et al. Detection of galactomannan antigenemia by enzyme immunoassay for the diagnosis of invasive aspergillosis., variables that affect performance. J Infect Dis, 2004, 190(3): 641-649.
  • 5Scotter JM, Campbell P, Anderson TP, et al. Comparison of PCRELISA and galactomannan detection for the diagnosis of invasive aspergillosis. Pathology, 2005, 37(3): 246-253.
  • 6Sulahian A, Touratier S, Ribaud P. False positive test for aspergillus antigenemia related to concomitant administration of piperacillin and tazobactam. N Engl J Med, 2003, 349(24):2366-2367.
  • 7Scotter JM, Campbell P, Anderson TP, et al. Comparison of PCR-ELISA and galactomannan detection for the diagnosis of invasive as-pergillosis. Pathology, 2005, 37(3).. 246-253.
  • 8Buchheidt D, Hummel M. Aspergillus polymerase chain reaction(PCR) diagnosis. Med Mycol, 2005, 43(Suppl 1):S139-S145.
  • 9I.ass-Florl C, Speth C, Mayr A, et al. Diagnosing and monitoring of invasive aspergillosis during antifungal therapy by polymerase chain reaction, an experimental study in mice. Diagn Microbiol Infect Dis, 2003, 47(4): 569-572.
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同被引文献43

  • 1黄晓军.血液病/恶性肿瘤患者侵袭性真菌感染的诊断标准与治疗原则(草案)[J].中华内科杂志,2005,44(7):554-556. 被引量：423
  • 2Mennink-Kersten MA,Donnelly JP,Verweij PE.Detection of circulating galactomannan for the diagnosis and management of invasive aspergillosis[J].Lancet Infect Dis,2004,4 (6):349-357.
  • 3Koldehoff M,Zaktzewski J.Modern management of respiratory failure due to pulmonary mycoses following al-logeneic haematopoietic stem cells transplantation[J],Am J Haematol,2005,79 (2):158.
  • 4Senn L,Robinson JO,Schmidt S,et al.1,3-Beta-D-glucan antigenemia for early diagnosis of invasive fungal infections in neutropenic patients with acute leukemia[J].Clin Infect Dis,2008,46(6):878-885.
  • 5Odabasi Z,Mattiuzzi G,Estey E,et al.β-D-Glucan as a di-agnostic adjunct for invasive fungal infections:validation,cutoff development,and performance in patients with a-cute myelogenous leukemia and myelodysplastic syndrome[J].Clin Infect Dis,2004,39(2),199-205.
  • 6Akamatsu N,Sugawara Y,Kaneko J,et al.Preemptive treatment of fungal infection based on plasma (1,3) beta-D-glucan levels after liver transplantation[J].Infection,2007,35(5),346-351.
  • 7Kedzierska A,Kochan P,Pietrzyk A,et al.Current status of fungal cell wall components in the immunodiagnostics of invasive fungal infections in humans,galactomannan,mannan and (1,3)-beta-D-glucan antigens[J].Eur J Clin Microbiol Infect Dis,2007,26(11),755-766.
  • 8Pryce TM,Kay ID,Palladino S,et al.Real-time automated polymerase chain reaction (PCR) to detect Candida and Aspergillus fumigatus DNA in whole blood from high-risk patients[J].Diagn Microbiol Infect Dis,2003,47(3):487-96.
  • 9Hebart H,Loffer J,Meisner C,et al.Early detection of aspergillus infection after allogeneic stem cell transplantation by polymerase chain reaction screening[J].J Infect Dis,2000,181 (5):1713-9.
  • 10Bretagne S.Molecular diagnostics in clinical parasitology and mycology:limits of current polymerase chain reaction (PCR) assays and interest of the real-time PCR assays[J].Clin Microbiol Infect,2003,9(6):505-11.

引证文献5

二级引证文献23

国际检验医学杂志
2006年 第10期

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