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恶性胶质细胞瘤的再手术治疗 被引量:1

Reoperation in the Treatment of Recurrent Intracranial Malignant Gliomas
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摘要 本文报告44例恶性胶质细胞瘤病人的再手术效果,其中多形胶质母细胞瘤13例(29.6%),星形细胞瘤Ⅲ~Ⅳ级31例(70.4%);第一二次手术间隔平均为78.5周;再手术前KR为20~90(平均56):8例病人接受一次以上再手术.手术死亡率为每次手术1.9%;再手术后平均存活期为52.7周:35例(79.5%)术后一个月时KR较术前改善,术后KR≥60的时间平均为25.2周;术前KR≥60、手术间隔时间>6个月、术中全切肿瘤的病人术后生存期较相应组明显延长(P<0.001).提出再手术治疗复发性恶性胶质瘤是可行的,但术前KR≥60,手术间隔>6个月及术中全切肿瘤者将获得较好效果. Fourty-four consecutive patients with recurrent intracranial malignant gliomaswere reoperated from 1985 to 1995. Thirteen patients (29. 6%) had glioblastoma multiforme, and31 (70. 4% ) had astrocytoma grade Ⅲ~Ⅳ. The median interval between the first operation andreoperation was 78. 5 weeks. The Karnofsky rating before reoperation ranged from 20 to 90 (me-dian, 56). Eight patients had more than one reoperation. The mortality rate was 1. 9% per proce-dure. The median survival after reoperation was 52. 7 weeks. Thirty-five patients (79. 5%) hadimproved KR at one month after reoperation. The median KR≥60 time after reoperation was 25.2 weeks. Patients with KR≥60, with interval>6 months, or in whom gross total removal of thetumor was undertaken lived longer than their respective counterparts. Reoperation is feasible forthe treatment of recurrent intracranial malignant gliomas and the patients described above will getbetter results.
出处 《海军总医院学报》 1996年第4期220-224,共5页 Journal of Naval General Hospital of PLA
关键词 恶性 胶质细胞瘤 再手术 治疗 Malignant Gliomas Reoperation
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