香茶菜甲素乙酰化物对缺血再灌注损伤的作用

Effect of Acetylamethystoidin A on Ischemia Reperfusion Injury Rats/

实验观察离体大鼠工作心脏停灌注４０ｍｉｎ再灌注２５ｍｉｎ后，发现其心肌超微结构严重损伤，乳酸脱氢酶（ＬＤＨ）及丙二醛（ＭＤＡ）生成量明显增加。同时发现香茶菜甲素乙酰化物可降低心肌超微结构的损伤程度，减少ＬＤＨ及ＭＤＡ的生成量。

In isolated working rat hearts ischemed 40min followed by reperfusion 25min, the myocardial ultrastructure was serious injuried, the release of lactic dehydrogenase (LDH) and malondialdehyde (MDA) were significantly increased. Acetylamethystoidin A reduced the damage of myocardial ultrastructure, decreased the releaseof LDH and MDA. It suggested that acetylamethystoidin A has protective effect to myocardial injury reperfusion.