摘要
采用电子显微镜观察沙鼠急性缺血再灌注后内皮细胞的变化及山莨菪碱对其的作用，结果发现缺血再灌注组脑血管内皮细胞间隙增宽，紧密连接破坏，采用电子顺磁共振法测定自由基单位重量积分强度为５２９２１．１４２±２．７６５；山莨菪碱组脑血管内皮细胞损伤明显减轻，并且自由基单位重量积分强度为３５５６２．９２６±８．１３７（Ｐ＜０．０５）。
The role of free radicals and cerebrovascular endothelial cell in post ischemic injury is studied. The brain ischemia reperfusion model was produced in mongolian gerbil. Free radicals determination by ESR, ultrastructural observation by electron microscopy. Results showed that anisodamine treated reperfusion group showed improvement in cerebrovascular endotheliocytic lesion as compared to untreated reperfusion group; that free radicals levels were significantly decreased in anisodamine treated repeifusion group as compared to untreated reperfusion ( P < 0.05 ).
出处
《微循环学杂志》
1996年第4期15-16,共2页
Chinese Journal of Microcirculation
关键词
脑缺血
血管内皮细胞
自由基
山莨菪碱
Post ischemic injury, brain
Endothelial cell, cerebrovascular
Free radicals
Anisodamine
