依那普利对糖尿病合并高血压患者甲襞微循环的影响

Page 21/Nailfold Microcirculation Changes During Enalapril Therapy for Diabetes with Hypertension

随机观察应用依那普利治疗３８例Ⅱ型糖尿病合并高血压患者甲襞微循环（ＮＭＣ）的变化，依那普利每日５～３０ｍｇ，分二次口服，与口服尼群地平３６例比较。治疗前，糖尿病合并高血压患者均有不同程度ＮＭＣ异常。依那普利治疗１２周ＮＭＣ总改善率９４．７％。糖尿病与高血压病程愈长，ＮＭＣ总改善率愈低。观察同时发现，依那普利治疗优于尼群地平。

38 cases of nonisulin dependent diabetes mellitus and hypertansion were treated with enalapril (5￣30mg/d, bid) according to a randomized treatment schedule, and 36 patients received nitrendipine as controls. The results indicate that nailfold microcirculation (NMC) abnormalities before treatment all patients. 38 patients were treated by enalapril after 12 weeks, NMC abnormalities total improvement rate 94.7 %. The period of diabetes mellitus and hypertension lengthened, improvement rate was reduced. Enalapril group showed better effects than that of the control group.