海马结构的MRI体积测量

MRI Volumetric Measurement of Hippocampal Formation

目的:测量中国正常成人海马结构(Hippocampal Formation,HPF)的体积.材料和方法:选择45例中国正常成人(男29例,女16例),用1.0T MR扫描仪进行研究.垂直于HPF长轴做倾斜的冠状面T1加权象,TR/TE500ms/20ms,5mm层厚,无间隔.在每个断面上手工描绘出HPF的边界,计算出双侧HPF的体积,用头颅大小进行标准化处理,然后分析HPF体积与年龄、利手及性别的关系.结果:中国正常成人HPF的体积,右侧为2.88cm^3～3.80cm^3,左侧为2.67cm^3～3.15cm^3,右侧HPF大于左侧,HPF的体积与年龄(20岁一49岁)性别及利手无关(P>0.05).结论:通过本研究获得了我国正常成人HPF体积数据,可进一步用于颞叶癫痫等病人的研究.

Purpose:The pumose of our study is to measure volume of Hippocampal Formation (HPFs)innormal Chinese adults. Materials and methods: Forty - five normal Chinese adults (24 male, 16female) were studied with 1. 0 Tesla MR scanner. T1 weighted images were aquired in obliquecoronal direction perpendicular to long axis of HPFs, TP/TE 500ms/20ms, thickness 5mm, nogap. The margins of HPFs were outlined mannually. The volume of HPFs of both side wasmeasured. And it was standardized to eliminate the effect of skull size. The relationship be-tween the volume of HPF,and age handness,sex were analysed .Results:The volum of HPFs innormal Chinese adults was 2. 88cm3 - 3. 80cm3 (Right), 2. 67cm3 - 3. 15cm3 (left), The volume ofright HPFs was larger than that of left ones. Age(20 - 49yr), sex and handness had no sig-nificant effect on the standardized volume of HPFs(P > 0. 05). Conclusion: The volumeparameter of HPFs in normal Chinese adults was aquired, It would be useful for the charac-terization of temporal lobe epilepsy and the early diagnosis of Alzheimer's disease.