基于非线性控制模型的药物动力学的问题研究

Research on Questions of Pharmacokinetic Based on Nonlinear Control Model

在临床和临床前的研究中,确定最大的可允许的剂量水平可以避免化学药品导致的毒性．通过血流灌注限制性的消除隔室模型,完成对药物在人体中处置过程的预测,并能得到机体功能的生理或病理改变所引起的药物配置动力学的变化．本文针对生理药物动力学的特点,利用模糊控制模型,并结合生理药物动力学,给出其了动态输出反馈控制方法．

In clinical and preclinical study, determine the allowed maximum dose level can avoid the toxicity caused by chemical medicine. By establishing the blood flow restricted compartment model, the prediction of drug operative period in human and the change of pharmacokinetic can be achieved. On the basis of the feature of pharmacokinetic, a class of output feedback controller based on the fuzzy model is presented in the paper.