摘要
流行病学调查表明在许多国家寄生虫感染率和自身免疫性疾病的发病率往往呈负相关,提示寄生虫感染对自身免疫性疾病可能有保护作用。早期的研究表明,Th1/Th2细胞活性的相对平衡对机体局部和全身的免疫及病理状况都有直接影响。自身免疫性疾病往往伴随着Th1细胞的过度活动；而蠕虫感染却常可诱导一个偏向于Th2细胞的反应。综合以上事实,有理由推测,某些寄生虫感染对某些自身免疫性疾病可能有一定的保护作用。
The epidemiological survey shows that there is an inverse relationship between autoimmune diseases and parasites infection, indicating the possible protective effects of the infection. It has been documented that the relative balance between Th1 and Th2 cells directly influences the systemic as well as the local immune and pathological conditions. The onset of autoimmune diseases usually accompanies an over activity of Th1 cells, while the infection of helminths usually induces a Th2 cells reaction.So it is possible that infection with some parasites may inhibit some autoimmune diseases.
出处
《国际医学寄生虫病杂志》
CAS
2006年第5期264-268,共5页
International JOurnal of Medical Parasitic Diseases
