急性脑梗塞患者血清肿瘤坏死因子增高

Elevated Serum Tumor Necrosis Factors in Patients with Acute Cerebral Infarction

采用放射免疫法测定４５例急性脑梗塞患者血清肿瘤坏死因子（ＴＮＦ）含量，并与３０例脑动脉硬化患者及２７例健康体检者进行比较。结果表明脑梗塞患者ＴＮＦ水平明显增高，脑梗塞组ＴＮＦ为７．１９±１．６７ｎｇ／ｍｌ，脑动脉硬化组为２．３０±１．０６ｎｇ／ｍｌ，正常对照组为１．４１±０．２３ｎｇ／ｍｌ。脑梗塞组与脑动脉硬化组比较有显著性差异（Ｐ＜０．００１）；与正常对照组比较有极显著性差异（Ｐ＜０．００１）。重型脑梗塞患者血清ＴＮＦ含量亦较轻型患者显著增高。重型ＴＮＦ含量为１１．３２±１．４３ｎｇ／ｍｌ，轻型为６．９０±１．５０ｎｇ／ｍｌ（Ｐ＜０．０５）。提示ＴＮＦ参与脑梗塞的发生、发展全过程，脑梗塞患者血清ＴＮＦ含量测定可作为判断患者病情、治疗及预后的一项免疫学指标。

Concentrations of serum tumor necrosis factor(TNF)were determined by radioimmunoassay in 45 patients with acute cerebral infarction, 30 patients with cerebral atherosclerosis and 27 healthy subjects. The results showed that the TNF concentrations in patients with cerebral infarction were significantly higher(7.19±1.67 ng/ml) than in patients with cerebral atherosclerosis(2.30±1.06 ng/ml,P<0.01) and in control subjects(1.41±0.23ng/ml,P<0.001).The TNF concentrations in severe patients were significantly higher (11. 32± 1.43 ng/ml) than in mild patients(6. 90± 1.50 ng/ml,P<0. 05).The possible mechanisms of the elevated TNF concentrations in patients with cerebral infarction were discussed.