期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

IL-21的免疫调节作用 被引量：2

Immunoregulatory Function of IL-21
原文传递
导出
摘要 IL-21是近几年来被发现和关注的细胞因子,由活化的T细胞合成和分泌,主要通过激活NK细胞来发挥功能。已有的研究表明IL-21还可对T、B细胞和DC发挥重要的调节作用,并可能在促进天然免疫向获得性免疫转化中扮演了重要角色。 Accumulated data have shown IL-21 secreted by active T cells can activate NK cells and regulate the function of T cells, B cells, and dendritic cells （DC）. IL-21 play an important role in promoting the transforming of innate immunity to acquired immunity.
作者 徐林 熊思东（审校）
机构地区 复旦大学上海医学院免疫学系 复旦大学上海医学院免疫学系
出处 《国际免疫学杂志》 CAS 2006年第6期354-356,共3页 International Journal of Immunology
关键词 IL-21 天然免疫 获得性免疫 IL-21 Innate immunity Acquired immunity
分类号 R392.11 [医药卫生—免疫学]
  • 相关文献

参考文献18

  • 1Parrish N,Stacey RD,Andrew N,et al.Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.Nature,2000,6808(408):57-63.
  • 2Habib T,Senadheera S,Weinberg K,et al.The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3.Biochemistry,2002,41 (27):8725-8731.
  • 3Brady J,Hayakawa Y,Smyth MJ,et al.IL-21 induces the functional maturation of murine NK cells.J Immunol,2004,172 (4):2048-2058.
  • 4Burgess SJ,Marusina AI,Pathmanathan I,et al.IL-21 down-regulates NKG2D/DAP10 expression on human NK and CD8+ T cells.J Immunol,2006,176 (3):1490-1497.
  • 5Ma HL,Whitters MJ,Konz RF.IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma.J Immunol,2003,171(2):608-615.
  • 6Takaki R,Hayakawa Y,Nelson A,et al.IL-21 enhances tumor rejection through a NKG2D-dependent mechanism.J Immunol,2005,175(4):2167-2173.
  • 7Ettinger R,Sims GP,Fairhurst AM,et al.II-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells.J Immunol,2005,175(12):7867-7879.
  • 8Pene J,Gauchat JF,Lecart S,et al.Cutting edge:IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells.J Immunol,2004,172(9):5154-5157.
  • 9Totero D,Meazza R,Zupo S,et al.Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells.Blood,2006,107(9):3708-3715.
  • 10Jin H,Carrio R,Yu A,et al.Distinct activation signals determine whether IL-21 induces B cell costimulation,growth arrest,or Bimdependent apoptosis.J Immunol,2004,173(1):657-665.

同被引文献11

  • 1董昭兴,邰文琳,雷雯,邹华,付立主,张涛,王殿华.IL-17A在博来霉素致小鼠肺纤维化形成中的表达[J].西安交通大学学报（医学版）,2012,33(2):199-202. 被引量：13
  • 2张霞,欧阳学农,李晓冬,陈樟树,赵健,郭亚军.肠癌组织中TIP30基因的表达与转移、预后间的关系及机制[J].第二军医大学学报,2005,26(5):488-491. 被引量：20
  • 3Parrish-novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its re- ceptor are involved in NK cell expansion and regulation of lympho- cyte function[ J ]. Nature, 2000,408 (6808) : 57-63.
  • 4Borte S,Pan-Hammarstrom Q,Liu C,et al. Interleukin-21 restores immunoglobulin production ex vivo in patients with common variable immunodeficiency and selective lgA deficiency[ J ]. Blood, 2009,114 (19) :4089-4098.
  • 5Monteleone G, Sarra M, Pallone F. Interleukin-21 in T cell-mediated diseases[ J 1. Discov Med, 2009,8(42): 113-117.
  • 6Castellani ML, Salini V, Frydas S, et al.The proinflammatory inter- leukin-21 elicits anti-tumor response and mediates autoimmunity [ J]. Int J Immunopathol Pharmacol, 2006,19(2) : 247-251.
  • 7Kim HJ,Kazi JU,Lee YR,et al.Visualization of the melanosome transfer-inhibition in a mouse epidermal cell co-culture model[J]. Int J Mol Med, 2010,25(2) : 249-253.
  • 8Yao H, Bethel-Brown C,Buch S. Cocaine exposure results in forma- tion of dendritic varicosity in rat primary hippocampal neurons[J]. Am J Infect Dis,2009,5( 1 ) :26-30.
  • 9Sun A, Bagella L,Tutton S, et al. From Go to S phase:A view of the roles played by the retinoblastoma (Rb) family members in the Rb- E2F pathway[ J].J Cell Biochem,2007,102(6) : 1400-1404.
  • 10杨梁梓,张济州,吕路艳,李青.肺纤维化的研究进展[J].云南中医中药杂志,2010,31(8):74-76. 被引量：6

引证文献2

二级引证文献5

国际免疫学杂志
2006年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部