CD4^+CD25^+Tr细胞趋化性细胞因子受体表达的生物学意义研究

The Study of Chemokine Receptors Expressing on CD4^+CD25^+Tr Cells

CD4+CD25+调节性T(Tr)细胞在维持外周自身耐受从而防止自身免疫病的发生、抑制严重的炎症性疾病和下调肿瘤免疫应答中发挥着重要的作用。然而关于它们的免疫抑制机制的分子基础和迁移特性仍不明确。对CD4+CD25+Tr细胞上趋化性细胞因子受体表达的研究将有助于我们更好地了解这群细胞的作用机制。了解CD4+CD25+Tr细胞、趋化性细胞因子、趋化性细胞因子受体和表达于CD4+CD25+Tr细胞上的趋化性细胞因子受体以及它们与不同的抗原提呈细胞(APCs)之间的作用的最新研究进展十分必要。

CD4^＋ CD25^＋ regulatory T （Tr） cells play a critical role in the maintenance of self-tolerance, preventing autoimmune disease, inhibiting harmful infectious diseases and down-regulating anti-tumour immune response. However, the molecular basis of immunosup- pressive and the trafficking properties of these cells are unknown. Studying the chemokine receptors expressing on CD^4＋ CD25^ ＋ Tr cells will help us to understand the mechanism of this subset more clearly. This review focuses on recent advances in understanding the CD4^＋CD25^＋ regulatory T cells, chemokine and receptor, chemokine receptor expressing on CD4^＋ CD25^＋ Tr cells and the attraction of these cells by antigen presenting cells （APCs）.