可溶性CD83与免疫抑制

Soluble CD83 and Immunosuppression

CD83是树突状细胞(DC)上重要的表面标志,同时也是重要的功能分子。对CD83功能的认识是从对可溶性CD83(sCD83)研究开始的。sCD83主要通过膜结合型CD83(mCD83)蛋白水解形成,存在于正常人血清中,具有免疫抑制活性。sCD83通过影响细胞骨架抑制DC的功能。在某些血液病和病毒感染患者血清内浓度升高,并引起免疫抑制,导致血液肿瘤细胞和病毒的免疫逃逸。sCD83能够显著抑制实验性自身免疫病病变的发生,在治疗自身免疫病方面展示了广阔的前景。

CD83, an important surface marker on dendritic cells, is also a significant functional molecule. The recognition of CD83＇s function was from the study of the soluble form of CD83 （sCD83）. sCD83 ,which can be detected in the serum of health adults, has been found the activity of immunosuppression, sCD83 is mainly produced by proteolysis of membrane CD83 （mCD83）. sCD83 inhibits the function of dendritic cells by changing the cystoskeleton. In some patients with leukemia and viral infection, the serumal level of sCD83 increases, resulting in immunosuppression, as well as blood tumor cells and virus escape immune surveillance, sCD83 can remarkably inhibit the development of experimental autoimmune disease, which show great prospect in its therapeutic value on this kind of disease.