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Fas／FasL系统参与的几种生物学效应 被引量：20

Fas/FasL System in Kinds of Biological Effects
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摘要 Fas／FasL通路是介导细胞凋亡的一条重要途径。近年来的研究表明,它参与了胸腺选择、免疫赦免以及协调了免疫反应的平衡,同时它亦与一些肿瘤的发生发展、移植排斥、自身免疫性疾病的产生以及诸多的生理病理反应密切相关。 Fas/FasL is one important signal pathway mediating cell apoptosis. Recent studies show that it participates many biological effects, such as Graft Rejection,Immune Privilege ,Autoimmune Disease and it also plays an important role in the development of many kinds of tumors. Further reseach on this signal pathway will help to understand a lot of physiological and pathological problems. In this article, the latest advancements on Fas/FasL pathway will be introduced.
作者 桑威 徐开林（审校） 潘秀英（审校）
机构地区 徐州医学院附属医院血液科硕士研究生 徐州医学院附属医院血液科
出处 《国际免疫学杂志》 CAS 2006年第6期389-392,共4页 International Journal of Immunology
关键词 FAS/FASL 凋亡 GVHD Allo—HSCT Fas/FasL Apoptosis GVHD Allo - HSCT
分类号 R392.11 [医药卫生—免疫学]
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参考文献18

  • 1Bohana-Kashtan O,Civin Cl.Fas ligand as a tool for immunosuppression and generation of immune tolerance.Stem Cells,2004,22 (6):908-924.
  • 2Orlinick JR,Vaishnaw AK,Elkon KB.Structure and function of Fas/Fas ligand.Int Rev Immunol,1999,18 (4):293-308.
  • 3Ross MJ,Martinka S,D'Agati VD,et al.NF-kappaB regulates Fasmediated apoptosis in HIV-associated nephropathy.J Am Soc Nephrol,2005,16 (8):2403-2411.
  • 4Iwase M,Kondo G,Watanabe H,et al.Regulation of fas-mediated apoptosis in neutrophils after surgery induced acute inflammation.J Surg Res,2006,134(1):114-123.
  • 5Hu WS,Wang ZP,Dong MY,et al.Expression of Fas and FasL in serum and placenta of preeclamptic pregnancy and its significance.Zhejiang Da Xue Xue Bao Yi Xue Ban,2005,34(6):499-502.
  • 6Landau AM,Luk KC,Jones ML,et al.Defective Fas expression exacerbates neurotoxicity in a model of Parkinson's disease.J Exp Med,2005,202(5):575-581.
  • 7Groh V,Smythe K,Dai Z,et al.Fas ligand-mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity.Nat Immunol,2006,7 (7):755-762.
  • 8Plumas J,Chaperot L,Richard M J,et al.Mesenchymal stem cells induce apoptosis of activated T cells.Leukemia,2005,19 (9):1597-1604.
  • 9Dotti G,Savoldo B,Pule M,et al.Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis.Blood,2005,105(12):4677-4684.
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同被引文献161

引证文献20

二级引证文献93

国际免疫学杂志
2006年 第6期

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