胞磷胆碱与常用输液配伍的体外稳定性探讨

Study about extrasomatic stability of citicoline in common solution

目的：探讨胞磷胆碱在常用静脉输液中的体外稳定性。方法：将胞磷胆碱0．75g分别用10％葡萄糖注射液、5％葡萄糖氯化钠注射液、生理盐水、半张液和极化液250ml溶解，室温下放置，于0h、2h、4h、6h观察溶液外观、检查澄清度、测pH值，并用高效液相色谱法测定每个时间．占、上胞磷胆碱药物浓度。结果：所有溶液在0h、2h、4h、6h不同时点均保持清澈，无变色出现，无杂质、结晶、沉淀和气泡生成；所有溶液各个检查时点pH值基本保持不变．变化范围0．04～0．18（P〉0．05）。胞磷胆碱在10％葡萄糖注射液、5％葡萄糖氯化钠注射液、生理盐水、半张液和极化液中浓度保持稳定。结论：胞磷胆碱在10％葡萄糖注射液、5％葡萄糖氟化钠注射液、生理盐水、半张液和极化液中体外稳定性好。

Objective ：To investigate extrasomatic stability of citicoline injection in common solution. Methods：Dissolution 0.75g citicoline into 250ml 10% glucose injection,5% glucose saline, physiological saline, half - tension liquid and polarized liquid respectively, preservation in subnormal temperature. Concentrations of citicoline were determined in 0 hour, 2 hour,4 hour and 6 hour by HPLC method;Guise of solution,pH scale and clarity were determined too,respectively. Results ： All guise of solution were clarifying. All solution production were not foreign material, crystal, precipitation and air cell. All solution pH scale and concentrations of citicoline were not significance change. Conclusion ： Extrasomatic stability of citicoline in common solution were favorable.