多发性硬化治疗药物的不良反应及其防治措施

Adverse drug reactions of the medicines for the treatment of multiple sclerosis and their therapy measures

本文介绍了治疗多发性硬化的三类药物,包括β干扰素系列、醋酸格拉默(glatiramer acetate)和米托蒽醌(mitoxantrone),阐述了上述药物的不良反应,主要有肝功能损害、造血系统影响、心肌毒性、注射部位反应和注射后流感样症状、抑郁症,并针对性地制定治疗及预防措施。

In this article, three kinds of medicines which are approved for the treatment of multiple sclerosis （MS） are introduced, including three interferon （IFN） products, glatiramer acetate and mitoxantrone. Drug adverse reactions profiles of these medicines, including liver function damage, hemopoietic system lesion, cardiotoxicity, injection-site reactions, influenzalike symptoms and depression are mainly discussed. Moreover practical measures to manage the adverse events are provided.