摘要
目的:探讨人类白细胞抗原(human leukocyte antigen,HLA)配型、群体反应性抗体(panel reactive antibody,PRA)与心脏移植术后急性排斥反应及近期生存的关系。方法:将心脏移植受者根据不同的HLA配型标准,按错配数分组;根据PRA检测阳性或阴性分组。统计各组术后3、6、12个月内急性排斥反应发生率并行生存分析。结果:HLA配型不同错配数组间急性排斥反应发生率及生存曲线无显著差异;PRA阳性和阴性组间急性排斥反应发生率及生存曲线也无显著差异。结论:就我国目前国情而言,心脏移植术前不进行常规HLA配型也是可行的,PRA阳性者通过适当的干预治疗也可获得安全的移植。
Objective：To investigate the role of HLA typing and PRA testing in heart transplantation. Methods： Recipients were grouped according to different HLA typing criteria or PRA testing results. Acute rejection within 3,6,12 months after transplantation and short--term survival curves were analyzed respectively. Results： There was no significant difference of a cute rejection and short--term survival curves between different HLA mismatching groups or between PRA positive and nega rive groups. Conclusion：It is feasible not routinely typing HLA before heart transplantation in present practice. PRA positive recipients could also acquire safe transplantation through appropriate therapy.
出处
《中国临床医学》
北大核心
2006年第5期703-704,共2页
Chinese Journal of Clinical Medicine
基金
上海市科委重大项目(NO.024119001)
关键词
心脏移植
人类白细胞抗原
群体反应性抗体
Heart transplantation
Human leukocyte antigen（HLA）
Panel reactive antibody（PRA）
