短暂性脑缺血发作患者颈动脉粥样硬化斑块和血浆基质金属蛋白酶-3的关系

The Relationship between Carotid Artery Plaque and Matrix Metalloproteinases-3 in Patients with Transient Is-chemic Attacks

目的:研究短暂性脑缺血发作(TIA)患者颈动脉中层厚度(IMT)及斑块发生率和血浆基质金属蛋白酶-3(MMP-3)的血浆水平及两者的相关性。方法:用彩色多普勒超声检测26例有梗死TIA患者、30例无梗死TIA患者和30例健康对照组颈动脉IMT及斑块,用ELISA法测定血浆基质金属蛋白酶-3(MMP-3)。结果:与对照组相比,有梗死组和无梗死组的甘油三酯(TG)、总胆固醇(CHO)、低密度脂蛋白(LDL-C)的水平偏高,而高密度脂蛋白(HDL-C)则降低,有显著差异(P <0．05),有梗死组和无梗死组间比较无显著差异(P>0．05)。伴有脑梗死的TIA组与无梗死TIA组的颈动脉IMT明显高于对照组,两组的斑块发生率亦明显高于对照组,有显著差异(P<0．05),两组之间比较无差异。MMP-3的血浆水平在伴有脑梗死的TIA组明显升高,与无脑梗死和正常对照组比较有显著差异(P<0．05),而无梗死TIA组和正常对照组比较无显著差异(P>0．05)。蛄论:血浆MMP-3水平的提高、和颈动脉内膜中层增厚及斑块的不稳定性、TIA的形成和发展有着密切联系。

Objective：To study the intirna-media thickness （IMT）, plaque of the carotid artery and matrix metalloproteinase3（MMP-3） in patients with TIA and the relationship between MMP3 and the carotid IMT and plaque. Methods：Using highresolution ultrasonic instrument, IMT and the plaque in the carotid artery were detected in 26 TIA patients with cerebral in farction, 30 TIA patients without cerebral infarction and 30 control subjects. Serum concentration of MMP-3 was measured by enzyme linked immunoadsorbent assay （ELISA）. Results：Compared with control group, IMT, laque in the carotid artery in TIA patients with cerebral infarction and TIA patients without cerebral infarction significantly increased （P〈0. 051）. MMP-3 in TIA patiems with cerebral infarction were significantly increased （P〈0.05） as compared with that in TIA patients without cerebral and control group. Conclusion：There may be a close relation ship between serum level of MMP-3 with pathogeny and the induction of disruption of arteriosclerosis plaque. MMP-3 play an importam role in TIA.