大肠癌术中腹腔植入氟尿嘧啶植入剂的临床观察

Safety of Intraoperative Chemotherapy on Advanced Colorectal Cancer Patients with Sustained-release Fluorouracil

目的:探索进展期大肠癌术中腹腔植入氟尿嘧啶植入剂化疗的安全性,寻找预防大肠癌局部复发的新途径。方法: 51例大肠癌根治分成术中植入氟尿嘧啶植入剂组和空白对照组,氟尿嘧啶植入剂组在肿瘤创面和沿淋巴引流途径,分多点植入氟尿嘧啶植入剂。观察植药后伤口愈合,有无吻合口漏、肠梗阻,肝肾功能变化,以及住院天数等。结果:术中植入氟尿嘧啶植入剂组与对照组的血常规,吻合口漏、伤口感染、肠梗阻发生率以及住院天数无明显异常;两组治疗后血白细胞计数、ALT和肌酐较治疗前有明显升高(P<0．05);但两组间无显著差异(P>0．05)。结论:大肠癌根治术中植入氟尿嘧啶植入剂安全可靠,是术后局部区域性化疗的有效途径。

Objective：To explore the way of intraoperative chemotherapy to prevent the local recurrence of colorectal cancer after operation. Methods：51 patients with colorectal cancer, were randomly divided into controlled group and sustained-release fluorouracil group. The tumor was surgically removed and sustained release fluorouracil were implanted multiple point during operation in the tumor cavity to observe the incidence of wound infection, anastomosis leakage, intestinal obstruction and wound infection and days of in-hospital. WBC, RBC, ALT and Cr were also observed. Results： The difference of side effects and postoperative complications between controlled group and sustained-release fluorouracil group was not obviously. WBC, ALT and Cr were different before and after operation, but the difference of two group was not obviously. Conclusion： The method of intra-operative implanted sustained-release fluorouracil is safe, and it might become a new promising method to prevent postoperative local recurrence of colorectal cancer.