SLE基因芯片表达谱研究进展

The Gene Expression Profiling of Systemic Lupus Erythematosus

基因表达谱的研究揭示了系统性红斑狼疮病理过程和糖皮质激素治疗系统性红斑狼疮时众多基因表达异常,涉及很多基因家族和功能簇,这种细胞全景式基因表达是特定研究条件下各种因素综合作用的结果,其原因和机制均很复杂,需结合其他分子生物学技术才能加以证实和阐明。

The gene expression profiling revealed that a lot of genes have been observed unique expression in SLE in both pathologic progress and glucocorticoid therapy practice. These global cellular genetic unique expressions which were embroiled many gene families and clusters are an integrated result of various factors under the particular research condition. These gene unique expressions have complicated etiologies and mechanisms which are verified and elucidated frequently by genechip combined with other molecular biologic methods