静脉注射免疫球蛋白治疗自身免疫性大疱病的现状

Current Situation of the Application of Intravenous Immunoglobulin in Autoimmune Blistering Diseases

静脉注射免疫球蛋白作为一种免疫调节剂可治疗多种免疫相关性疾病。自身免疫性疱病是在皮肤科中使用静脉注射免疫球蛋白最有效的疾病之一。该方法不良反应较少且大多有自限性,为一些常规治疗禁忌或无效的患者提供了安全有效的治疗选择。但其确切的作用机制尚未完全明了,近年来的研究显示可能与抗独特型抗体、中和Fc受体、调节细胞因子网络、影响发病中的细胞凋亡过程等有关。

Intravenous immunoglobulin has been shown to be effective in the treatment of many immune-mediated diseases as an immunomodulatory agent. Autoimmune mucocutaneous blistering diseases are among those skin diseases which well respond to intravenous immunoglobulin with fewer adverse effects. Intravenous immunoglobulin may be an effective alternative therapy for patients who are contraindicate to or fail to conventional treatments. Rencently, numerous mechanisms have been proposes to explain the mode of action of intravenous immunoglobulin, including antiidiotypic antibodies, regulation of functions of Fc receptors, interference with the cytokine network, and anti-apoptotic effects, etc.