橄榄－桥脑－小脑萎缩（OPCA）的MRI与临床

Olivopontocerebellar Atrophy:MRI and Clinic

本文回顾性分析了４０例橄榄－桥脑－小脑萎缩（ＯＰＣＡ）的临床与ＭＲＩ。ＯＰＣＡ为一种变性疾病，分为遗传型与散发型二类。临床表现为进行性小脑性共济失调，可伴有锥体外系症状，锥体束征及直立性低血压。ＭＲＩ表现为小脑、脑干萎缩，尤其是小脑蚓部、桥脑最明显，并脑池相应扩大，ＭＲＩ优于ＣＴ，尤其是正中矢状面Ｔ１加权像显示桥脑与小脑蚓部萎缩最佳。

The clinical records and magnetic resonance imaging(MRI) in 40 patients with olivopontocerebellar atrophy(OPCA)were analysed retrospectively. OPCA is a degenerative disease that can been divided into hereditany and sporadic cases.Progressive cerebellar ataxia was the main clinical symptom, other manifestations included extrapyramidal system and pyramidal tract sign and orthostatic hypotension. MRI showed atrophy olf cerebellum and brainstem. The superior vermis of cerebellum and pons were more prominently involved.MRI especially midsagittal T1 weighted imaging was better than CT in demonstraing atrophy of superior vermis of cerebellum,as well as pons.