CD34在大肠癌中的表达及其意义

EXPRESSION AND SIGNIFICANCE OF CD34 IN CANCER OF COLON

目的:检测大肠癌中CD34的表达,探讨其在大肠癌发生、发展及转移中的作用。方法:应用流式细胞术检测80例大肠癌标本中CD34的表达。结果:CD34在大肠癌组织中的表达量明显高于正常大肠粘膜(P<0.01);不同Dukes分期之间、不同分化程度大肠癌组织之间CD34的表达差异有统计学意义(P<0.05-0.01)。结论:大肠癌中有血管形成,CD34可能是判断病人预后的指标。

Objective：To detect the expression of CD34 and investigate its＇ relations in Pathogenesis, development and metastasis of cancer of colon. Methods： Flow cytometry （FCM） was used to detect the expression of CD34 in 80 cases cancer of colon. Results： The expression of CD34 in cancer of colon was obviously higher than normal tissue （P〈0.01） ; the expression of CD34 was significantly associated with Dukes stages, and differentitated degree （P〈0.05-0. 01）. Conclusions： There has angiogenesis in cancer of colon, and the expression of CD34 may be a significant prognostic indicator.