尿胰蛋白酶原-2测定在急性胰腺炎诊断中的应用评价

Application estimate of measuring urinary trypsinogen-2 in diagnoses of acute pancreatitis

目的探讨尿胰蛋白酶原一2测定在急性胰腺炎诊断中的价值。方法对54例急性胰腺素患者、58例胆结石患者、47例肾结石患者和50例健康对照组人员进行尿胰蛋白酶原-2、尿淀粉酶和血清淀粉酶测定。结果54例急性胰腺炎中有52例尿胰蛋白酶原-2阳性,敏感性为96.3%;105例非急性胰腺炎患者中分别有6例脂结石患者和1肾结石患者l例共7例尿胰蛋白酶原-2呈阳性,特异性为93.3%。血淀粉酶敏感性为87.0%,特异性88.6%;尿淀粉酶敏感性85.2%,特异性83.8%。结论尿胰蛋白酶原-2测定是一个具有高敏感性和特异性的诊断急性胰腺炎的指标,优于尿淀粉酶和血淀粉酶。

Objective To estimate the application value of measuring urinary trypsinngen-2 in diagnose of acute pancreafitis. Methods Urinary trypsinogen-2,urinary amylase and serum amylase,lipase were assayed in 54 patients with acute pancreatitis,58 patents with choleIithiasis,47 patients with nephr01ith and 50 normal control beings. Results Urinary trypsinogen-2 was found in 52 patients with acute pancreafitis and 7 patients with non-panceatitis（6 patients with choleithiasis and 1 patients with nephrol ith）. The sensitivity and speificity of urinary trypsinogen-2 were 96.3% and 93.3% respctively： serum amylase test were 87.0% and 88.6% respectively,and urinary amylase test were 85.2% and 83.8% respectively, and serum 1 ipase were 89.2%and 94.5%respect ively. Conclusions Urinary trypsinOgen-2test is high sensitivity and specificity diagnostic method for acute pancreatitis.