辛伐他汀治疗高血压脑卒中并高脂血症的观察

Investigation on the effection and safety of simvastatin(shujiangzhi) on primary hyperlipidemia patients with hypertensive stroke

目的观察每天服用辛伐他汀(舒降之)20mg的降脂疗效及耐受性、对高血压脑卒中的疗效影响及对防止高血压脑卒中复发的作用。方法选取60例高血压脑卒中合并原发性高脂血症患者,随机分为两组即治疗组和对照组,治疗组每晚服用舒降之20mg,疗程为4周。观察前后对两组神经功能缺损程度进行评价,比较两组的疗效,并监测一年内两组脑卒中的复发情况。结果舒降之20mg/d可降低血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)分别为32.3%、27.3%、35.2%(P<0.01)降低TC、TG、LDL-C的总有效率为90%、73.3%、93.3%。治疗组患者神经功能缺损的恢复明显优于对照组。治疗组及对照组的复发率分别为6.67%、16.67%。结论每晚服用舒降之20mg,降脂疗效确切,不良反应较少,耐受性良好。有利于神经功能的恢复并能降低高血压脑卒中的复发率。

Objective To investigate the effection and safety of simvastatin （shujiangzhi） on primary hyperlipidemia patients with hypertensive stroke. Methods 60 patients were randomly divided into two groups：treatment group and control group.The treatment group was given orally simvastatin 20mg at night for 4 weeks. The degree of neurologic impairment were compared between two groups and the recurrence of stroke in two groups were monitored for one-year following-up.Results The serum levels of total cholesterol （TC）, triglycerides （TG） and low density lipoprotein-cholesterol （LDL-C） decreased respectively by 32.3%, 27.3%, 35.2% （P〈0.01）, and the total effective rate were 90%, 73.3%, 93.3% respectively. The recovery of the neurological impairment in treatment group was better than that of control group. The recurrent rate of treatment group and control group was 6.67% and 16.67% respectively. Conclusion The treatment of simvastatin 20mg daily achieved satisfactory effect and safety.The efficacy of simvastatin in lowering hyperlipidemia is defined with less side effects. It is helpful for the recovery of neurological impairment and can decrease the recurrent rate of stroke in hypertentive patients.